1. Natural Medicines Comprehensive Database. 3th ed. 2013. pp: 676; 1219-1223; 1416-1418.2. PDR for Herbal Medicine. 4th. 2008. pp: 322-323;580-582; 684-686.3. Kon R, Ikarashi N, Nagoya C, Takayama T, Kusunoki Y, Ishii M, Ueda H, Ochiai W, Machida Y, Sugita K, Sugiyama K: Rheinanthrone, a metabolite of sennoside A, triggers macrophage activation to decrease aquaporin-3 expression in the colon, causing the laxative effect of rhubarb extract. J Ethnopharmacol. 2014.27;152(1):190-200.4. Zhou YX, Xia W, Yue W, Peng C, Rahman K, Zhang H. A Review of Pharmacological Activities. Evid Based Complement Alternat Med. 2015;2015:578107